Dyshemoglobins and Pulse Oximetry: How COHb and MetHb Influence Measurement Accuracy   Pulse oximetry has become central to physiological monitoring across wearables, medical devices, and clinical research studies. Yet even the most advanced sensor architectures face fundamental challenges when hemoglobin exists in altered forms—known as dyshemoglobins . Carboxyhemoglobin (COHb) and methemoglobin (MetHb) change light absorption in ways that directly influence SpO₂ readings an

Engineering leaders developing physiological monitoring devices often encounter references to “arterial line measurements” in validation standards and technical literature. Although arterial lines are invasive and placed in clinical environments, the data they generate is central to how the industry defines accuracy for non-invasive technologies.  This article explains what an arterial line is, why its measurements are considered a benchmark, and how arterial line data is use

How PRL Ensures Data Integrity in Physiological Monitoring Research   For CTOs and technical leaders in MedTech, data integrity is not a paperwork detail—it is the backbone of regulator-ready evidence. Whether your device requires pulse oximetry testing during controlled desaturation in a hypoxia lab, multi-parameter wearables validation, or multi-site clinical research studies, every data point must be defensible. ALCOA+ provides the industry-standard framework for achieving

For medical device and wearable technology developers, the success of a clinical research study often hinges on one factor: the quality...

On September 16, 2025, the FDA issued a safety communication  warning consumers and healthcare providers about the risks of using...

Blood Pressure Monitoring: A Clinical Cornerstone   Blood pressure measurement is one of the most common clinical assessments, shaping...

Why Arterial Line Monitoring Matters in Research   When evaluating new medical devices—particularly those designed for physiological...

Why the Participant Experience Matters to Sponsors   For sponsors developing wearable medical devices, every detail of a clinical...